Leonard Shelby is tracking down the man who raped and murdered his wife. The difficulty of locating his wife's killer, however, is compounded by the fact that he suffers from a rare, untreatable form of short-term memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minutes ago, where he's going, or why.
When larcenous real estate clerk Marion Crane goes on the lam with a wad of cash and hopes of starting a new life, she ends up at the notorious Bates Motel, where manager Norman Bates cares for his housebound mother.
A tormented jazz musician finds himself lost in an enigmatic story involving murder, surveillance, gangsters, doppelgängers, and an impossible transformation inside a prison cell.
A journalist duo go on a tour of serial killer murder sites with two companions, unaware that one of them is a serial killer himself.
Mort Rainey, a writer just emerging from a painful divorce with his ex-wife, is stalked at his remote lake house by a psychotic stranger and would-be scribe who claims Rainey swiped his best story idea. But as Rainey endeavors to prove his innocence, he begins to question his own sanity.
Two FBI agents investigating the murder of civil rights workers during the 60s seek to breach the conspiracy of silence in a small Southern town where segregation divides black and white. The younger agent trained in FBI school runs up against the small town ways of his partner, a former sheriff.
Peter Winter is a young schizophrenic who is desperately trying to get his daughter back from her adoptive family. He attempts to function in a world that, for him, is filled with strange voices, electrical noise, disconcerting images, and jarringly sudden emotional shifts. During his quest, he runs afoul of the law and an ongoing murder investigation.
A self-assured businessman murders his employer, the husband of his mistress, which unintentionally provokes an ill-fated chain of events.
Reporter John Klein is plunged into a world of impossible terror and unthinkable chaos when fate draws him to a sleepy West Virginia town whose residents are being visited by a great winged shape that sows hideous nightmares and fevered visions.
Complete strangers stranded at a remote desert motel during a raging storm soon find themselves the target of a deranged murderer. As their numbers thin out, the travelers begin to turn on each other, as each tries to figure out who the killer is.
The murderous, backwoods Firefly family take to the road to escape the vengeful Sheriff Wydell, who is not afraid of being as ruthless as his target.