After being bitten by a genetically altered spider at Oscorp, nerdy but endearing high school student Peter Parker is endowed with amazing powers to become the superhero known as Spider-Man.
Peter Parker is going through a major identity crisis. Burned out from being Spider-Man, he decides to shelve his superhero alter ego, which leaves the city suffering in the wake of carnage left by the evil Doc Ock. In the meantime, Parker still can't act on his feelings for Mary Jane Watson, a girl he's loved since childhood. A certain anger begins to brew in his best friend Harry Osborn as well...
The seemingly invincible Spider-Man goes up against an all-new crop of villains—including the shape-shifting Sandman. While Spider-Man’s superpowers are altered by an alien organism, his alter ego, Peter Parker, deals with nemesis Eddie Brock and also gets caught up in a love triangle.
In order to save his dying father, young stunt cyclist Johnny Blaze sells his soul to Mephistopheles and sadly parts from the pure-hearted Roxanne Simpson, the love of his life. Years later, Johnny's path crosses again with Roxanne, now a go-getting reporter, and also with Mephistopheles, who offers to release Johnny's soul if Johnny becomes the fabled, fiery 'Ghost Rider'.
When the Hulk's presence on Earth becomes too great a risk, the Illuminati trick him to board a shuttle destined for a planet where he will be able to live in peace, and launch it into space. The Hulk's struggle to escape causes the shuttle to malfunction and crash land on the planet Sakaar, however, where he is sold into slavery and trained as a gladiator.
Blade forms an uneasy alliance with the vampire council in order to combat the Reapers, who are feeding on vampires.
The Daywalker known as "Blade" - a half-vampire, half-mortal man - becomes the protector of humanity against an underground army of vampires.
For years, Blade has fought against the vampires in the cover of the night. But now, after falling into the crosshairs of the FBI, he is forced out into the daylight, where he is driven to join forces with a clan of human vampire hunters he never knew existed—The Nightstalkers. Together with Abigail and Hannibal, two deftly trained Nightstalkers, Blade follows a trail of blood to the ancient creature that is also hunting him—the original vampire, Dracula.
Two mutants, Rogue and Wolverine, come to a private academy for their kind whose resident superhero team, the X-Men, must oppose a terrorist organization with similar powers.
Professor Charles Xavier and his team of genetically gifted superheroes face a rising tide of anti-mutant sentiment led by Col. William Stryker. Storm, Wolverine and Jean Grey must join their usual nemeses—Magneto and Mystique—to unhinge Stryker's scheme to exterminate all mutants.
When a cure is found to treat mutations, lines are drawn amongst the X-Men—led by Professor Charles Xavier—and the Brotherhood, a band of powerful mutants organised under Xavier's former ally, Magneto.