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As the west rapidly becomes civilized, a pair of outlaws in 1890s Wyoming find themselves pursued by a posse and decide to flee to South America in hopes of evading the law.

Jim Harvey is hired to guard a small wagon train as it makes its way west. The train is attacked by Indians and Harvey, hoping to persuade Aguila, the chief, to call off the attack due to Harvey's having saved his son's life, leaves the train to negotiate. He is captured and the rest of the train is wiped out except for two sisters. Escaping and showing up in town later, Harvey is nearly hanged as a deserter, but gets away. Eventually caught by the sheriff and his posse, they are attacked by Indians. This time the Indians are defeated and Aguila, captured and dying, reveals the identity of the white man who engineered the initial attack on the wagon train, just as the perpetrator rides up behind them.

As the railroad builders advance unstoppably through the Arizona desert on their way to the sea, Jill arrives in the small town of Flagstone with the intention of starting a new life.

At the beginning of the 1913 Mexican Revolution, greedy bandit Juan Miranda and idealist John H. Mallory, an Irish Republican Army explosives expert on the lam from the British, fall in with a band of revolutionaries plotting to strike a national bank. When it turns out that the government has been using the bank as a hiding place for illegally detained political prisoners - who are freed by the blast - Miranda becomes a revolutionary hero against his will.

The Man With No Name enters the Mexican village of San Miguel in the midst of a power struggle among the three Rojo brothers and sheriff John Baxter. When a regiment of Mexican soldiers bearing gold intended to pay for new weapons is waylaid by the Rojo brothers, the stranger inserts himself into the middle of the long-simmering battle, selling false information to both sides for his own benefit.

While the Civil War rages on between the Union and the Confederacy, three men – a quiet loner, a ruthless hitman, and a Mexican bandit – comb the American Southwest in search of a strongbox containing $200,000 in stolen gold.

Gunslinger Clayton Drumm is about to be hanged when he is given a chance to live if he agrees to murder Matthew, a miner who has steadfastly refused to sell his land to the railroad company. Matthew’s refusal is a major obstacle to the railroad’s plans for expansion.

Two wannabes rig a fight with a large prize fighter to buy a car.

A Texan sheriff and his younger brother travel across the border into Mexico to confront the man who killed their father.

A Mexican bandit is about to be executed in the United States, so his brother takes over a train and holds the passengers as hostages unless his brother is released. Now both the Americans and Mexicans are baffled as to what to do. One of the passengers — who wrote the letter for their captor — has a suggestion: call mercenaries Hank Brackett and Johnny Reech. They do, and as expected they do come up with a plan, but the president of the railroad is not sure if it will work.

Daniel Bone is aiming for success. A Brooklyn gunsmith by trade, he figures the place to be is where the guns are. So off he goes into the West and becomes the foe of the notorious Pecos Kid, the captive of Paiutes, the target in a saloon showdown, and the lone source of the whereabouts of a fabulous gold strike.