Lt. Col. Kirby Yorke is posted on the Texas frontier to defend settlers against depredations of marauding Apaches. Col. Yorke is under considerable stress by a serious shortage of troops of his command. Tension is added when Yorke's son (whom he hasn't seen in fifteen years), Trooper Jeff Yorke, is one of 18 recruits sent to the regiment.
Retired wealthy sea captain Jim McKay arrives in the Old West, where he becomes embroiled in a feud between his future father-in-law, Major Terrill, and the rough and lawless Hannasseys over a valuable patch of land.
Two friends hired to police a small town that is suffering under the rule of a rancher find their job complicated by the arrival of a young widow.
When attacked by two dogs, Joe Gilmore leaves them on the desert to die. Later one of the dogs saves John Blake from drowning. Men arrive claiming the dog is killing their chickens. They want to kill the dog but John convinces them the dog's fate should be determined by a trial.
When brash Texas border officer Mike Norton wrongfully kills and buries the friend and ranch hand of Pete Perkins, the latter is reminded of a promise he made to bury his friend, Melquiades Estrada, in his Mexican home town. He kidnaps Norton and exhumes Estrada's corpse, and the odd caravan sets out on horseback for Mexico.
Tex and his sidekicks arrive to help out his friend Jeffers, a railroad owner, only to find that he has been killed. They quickly run into trouble with an outlaw gang in their attempt to find the mysterious ghost train that supposedly runs on Jeffer's line.
After avenging his family's brutal murder, Wales is pursued by a pack of soldiers. He prefers to travel alone, but ragtag outcasts are drawn to him - and Wales can't bring himself to leave them unprotected.
A woman seeking revenge for her murdered father hires a famous gunman, but he's very different from what she expects.
Questions arise when Senator Stoddard attends the funeral of a local man named Tom Doniphon in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance. As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.
Ageing, wealthy, rancher and self-made man, George Washington McLintock is forced to deal with numerous personal and professional problems. Seemingly everyone wants a piece of his enormous farmstead, including high-ranking government men and nearby Native Americans. As McLintock tries to juggle his various adversaries, his wife—who left him two years previously—suddenly returns. But she isn't interested in George; she wants custody of their daughter.
When Rocklin arrives in a western town he finds that the rancher who hired him as a foreman has been murdered. He is out to solve the murder and thwart the scheming to take the ranch from its rightful owner.