When actress Sarah Marshall dumps aspiring musician Peter Bretter for rock star Aldous Snow, Peter's world comes crashing down. His best friend Brian suggests that Peter should get away from everything and to fly off to Hawaii to escape all his problems. After arriving in Hawaii and meeting the beautiful receptionist Rachel Jansen, Peter is shocked to see not only Aldous in Hawaii, but also Sarah.
Pushed to the breaking-up point after their latest 'why can't you do this one little thing for me?' argument, Brooke calls it quits with her boyfriend Gary. What follows is a hilarious series of remedies, war tactics, overtures and undermining tricks – all encouraged by the former couple's friends and confidantes …and the occasional total stranger! When neither ex is willing to move out of their shared apartment, the only solution is to continue living as hostile roommates until one of them reaches breaking point.
Bridget Jones is working as a TV host and still dating her new love, barrister Mark Darcy, for a perfect six weeks. But Bridget is jealous of the time Mark spends with a gorgeous co-worker Rebecca and, despite a vacation meant to smooth things over, ends their relationship. On assignment in Thailand with her disreputable ex, Daniel Cleaver - claiming to be a reformed man - they have a short dalliance, and she is arrested at the airport and temporarily jailed on the false accusation of drug smuggling before Mark, seemingly indifferent, comes to the rescue.
Pierre Lachenay is a well-known publisher and lecturer, married with Franca and father of Sabine, around 10. He starts a love affair with air hostess Nicole, which Pierre is hiding, but he cannot stand staying away from her.
Rebecca, an American who has been living in Jerusalem for a few months now, has just broken off her engagement. She gets into a cab driven by Hanna, an Israeli. But Hanna is on her way to Jordan, to the Free Zone, to pick up a large sum of money.
Five young New Yorkers throw their friend a going-away party the night that a monster the size of a skyscraper descends upon the city. Told from the point of view of their video camera, the film is a document of their attempt to survive the most surreal, horrifying event of their lives.
Bruno Stroszek is released from prison and warned to stop drinking. He has few skills and fewer expectations: with a glockenspiel and an accordion, he ekes out a living as a street musician. He befriends Eva, a prostitute down on her luck and they join his neighbor, Scheitz, an elderly eccentric, when he leaves Germany to live in Wisconsin.
After a painful breakup, Ben develops insomnia. To kill time, he starts working the late night shift at the local supermarket, where his artistic imagination runs wild.
After getting dumped for the 11th time in a row, Frankie discovers that she has a "loser in love" gene, which predisposes her to chronic failure and rejection for the rest of her life. She decides to embark on a quest to change her romantic future.
J.C. Wiatt is a talented and ambitious New York City career woman who is married to her job and working towards partner at her firm. She has a live-in relationship with Steven, a successful investment broker who, along with J.C., agreed children aren't part of the plan. J.C.'s life takes an unexpected turn when a distant relative dies and the will appoints her the caretaker of their baby girl, Elizabeth. The baby's sudden arrival causes Steven to leave, breaking off their relationship. Juggling power lunches and powdered formula, she is soon forced off the fast track by a conniving colleague and a bigoted boss. But she won't stay down for long. She'll prove to the world that a woman can have it all and on her own terms too!
Women enter and exit a science fiction author's life over the course of a few years after the author loses the woman he considers his one true love.