Blank-faced bug killer Bill Lee and his dead-eyed wife, Joan, like to get high on Bill's pest poisons while lounging with Beat poet pals. After meeting the devilish Dr. Benway, Bill gets a drug made from a centipede. Upon indulging, he accidentally kills Joan, takes orders from his typewriter-turned-cockroach, ends up in a constantly mutating Mediterranean city and learns that his hip friends have published his work - which he doesn't remember writing.
Charlie Kaufman is a confused L.A. screenwriter overwhelmed by feelings of inadequacy, sexual frustration, self-loathing, and by the screenwriting ambitions of his freeloading twin brother Donald. While struggling to adapt "The Orchid Thief," by Susan Orlean, Kaufman's life spins from pathetic to bizarre. The lives of Kaufman, Orlean's book, become strangely intertwined as each one's search for passion collides with the others'.
Mort Rainey, a writer just emerging from a painful divorce with his ex-wife, is stalked at his remote lake house by a psychotic stranger and would-be scribe who claims Rainey swiped his best story idea. But as Rainey endeavors to prove his innocence, he begins to question his own sanity.
A cashier poses as a writer for blacklisted talents to submit their work through, but the injustice around him pushes him to take a stand.
Holly Golightly is an eccentric New York City playgirl determined to marry a Brazilian millionaire. But when young writer Paul Varjak moves into her apartment building, her past threatens to get in their way.
Fresh out of university, a Turkish young man with literary aspirations returns to his home village, and to his father, a debt-ridden man with a gambling problem.
A young writer is invited to stay in a religious hostel run by a sinister, manipulative nun who plays deadly psychological games with the inhabitants.
The lives of Ted and Marion Cole are thrown into disarray when their two adolescent sons die in a car wreck. Marion withdraws from Ted and Ruth, the couple's daughter. Ted, a well-known writer, hires as his assistant a student named Eddie, who looks oddly similar to one of the Coles' dead sons. The couple separate, and Marion begins an affair with Eddie, while Ted has a dalliance with his neighbor Evelyn.
A celebration of love and creative inspiration takes place in the infamous, gaudy and glamorous Parisian nightclub, at the cusp of the 20th century. A young poet, who is plunged into the heady world of Moulin Rouge, begins a passionate affair with the club's most notorious and beautiful star.
Near a gray and unnamed city is the Zone, a place guarded by barbed wire and soldiers, and where the normal laws of physics are victim to frequent anomalies. A stalker guides two men into the Zone, specifically to an area in which deep-seated desires are granted.
A love triangle forms between post-Enlightenment writer Friedrich Schiller and two sisters - one who became his wife, and the other, his biographer.