A mute gunslinger fights in the defense of a group of outlaws and a vengeful young widow, against a group of ruthless bounty hunters.
As the railroad builders advance unstoppably through the Arizona desert on their way to the sea, Jill arrives in the small town of Flagstone with the intention of starting a new life.
At the beginning of the 1913 Mexican Revolution, greedy bandit Juan Miranda and idealist John H. Mallory, an Irish Republican Army explosives expert on the lam from the British, fall in with a band of revolutionaries plotting to strike a national bank. When it turns out that the government has been using the bank as a hiding place for illegally detained political prisoners - who are freed by the blast - Miranda becomes a revolutionary hero against his will.
The Man With No Name enters the Mexican village of San Miguel in the midst of a power struggle among the three Rojo brothers and sheriff John Baxter. When a regiment of Mexican soldiers bearing gold intended to pay for new weapons is waylaid by the Rojo brothers, the stranger inserts himself into the middle of the long-simmering battle, selling false information to both sides for his own benefit.
Wealthy rancher Bick Benedict and dirt-poor cowboy Jett Rink both woo Leslie Lynnton, a beautiful young woman from Maryland who is new to Texas. She marries Benedict, but she is shocked by the racial bigotry of the White Texans against the local people of Mexican descent. Rink discovers oil on a small plot of land, and while he uses his vast, new wealth to buy all the land surrounding the Benedict ranch, the Benedict's disagreement over prejudice fuels conflict that runs across generations.
Two bounty hunters both pursue the brutal and sadistic bandit, El Indio, who has a large bounty on his head.
While the Civil War rages on between the Union and the Confederacy, three men – a quiet loner, a ruthless hitman, and a Mexican bandit – comb the American Southwest in search of a strongbox containing $200,000 in stolen gold.
Lucky Luke becomes the Sheriff of Daisy Town and runs out all the criminals. Then the Dalton brothers arrive and try to get the Indians to break the peace treaty and attack the town.
Unofficial lawman John Corbett hunts down Cuchillo Sanchez, a Mexican peasant accused of raping and killing a 12-year-old girl.
A coffin-dragging gunslinger and a prostitute become embroiled in a bitter feud between a merciless masked clan and a band of Mexican revolutionaries.