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Corporate billionaire Edward Cole and working class mechanic Carter Chambers are worlds apart. At a crossroads in their lives, they share a hospital room and discover they have two things in common: a desire to spend the time they have left doing everything they ever wanted to do and an unrealized need to come to terms with who they are. Together they embark on the road trip of a lifetime, becoming friends along the way and learning to live life to the fullest, with insight and humor.

Trucker Rubber Duck and his buddies Pig Pen, Widow Woman and Spider Mike use their CB radios to warn one another of the presence of cops. But conniving Sheriff Wallace is hip to the truckers' tactics, and begins tricking the drivers through his own CB broadcasts. Facing constant harassment from the law, Rubber Duck and his pals use their radios to coordinate a vast convoy and rule the road.

When Erik Stifler realizes that he's the only Stifler family member who might graduate high school a virgin, he decides to live up to his legacy. After some well-meaning advice from Jim's dad, Erik's ready to take his chances at the annual and infamous Naked Mile race, where his devoted friends and some uninhibited sorority girls will create the most outrageous weekend ever.

With the help of an irreverent young sidekick, a bank robber gets his old gang back together to organise a daring new heist.

An irritable marketing executive, Neal Page, is heading home to Chicago for Thanksgiving when a number of delays force him to travel with a well meaning but overbearing shower curtain ring salesman, Del Griffith.

Tabloid reporters are sent by their editor to investigate after the paper recieves a letter from a woman claiming an angel is living with her.

Melvin Udall, a cranky, bigoted, obsessive-compulsive writer of romantic fiction, is rude to everyone he meets, including his gay neighbor, Simon. After Simon is brutally attacked and hospitalized, Melvin finds his life turned upside down when he has to look after Simon's dog. In addition, Carol, the only waitress at the local diner who will tolerate him, leaves work to care for her chronically ill son, making it impossible for Melvin to eat breakfast.

Two middle-aged men embark on a spiritual journey through Californian wine country. One is an unpublished novelist suffering from depression, and the other is only days away from walking down the aisle.

Manhattan drag queens Vida Boheme and Noxeema Jackson impress regional judges in competition, securing berths in the Nationals in Los Angeles. When the two meet pathetic drag novice Chi-Chi Rodriguez — one of the losers that evening — the charmed Vida and Noxeema agree to take the hopeless youngster under their joined wing. Soon the three set off on a madcap road trip across America and struggle to make it to Los Angeles in time.

After an Ithaca College student films his one-night stand with a beautiful sorority girl, he discovers one of his friends has accidentally mailed the homemade sex tape to his girlfriend in Austin. In a frenzy, he must borrow a car and hit the road in a desperate bid to intercept the tape.

A road trip to Los Angeles inadvertently leads a young man from Wyoming into a wild maze of psychotic hit-men, racy women, jewel thieves and a salsa band.