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At one of his many visits to his doctor, hypochondriac George Kimball mistakes a dying man's diagnosis for his own and believes he only has about two more weeks to live. Wanting to take care of his wife Judy, he doesn't tell her and tries to find her a new husband. When he finally does tell her, she quickly finds out he's not dying at all (while he doesn't) and she believes it's just a lame excuse to hide an affair, so she decides to leave him.

Playboy songwriter Brad Allen's succession of romances annoys his neighbor, interior designer Jan Morrow, who shares a telephone party line with him and hears all his breezy routines. After Jan unsuccessfully lodges a complaint against him, Brad sets about to seduce her in the guise of a sincere and upstanding Texas rancher. When mutual friend Jonathan discovers that his best friend is moving in on the girl he desires, however, sparks fly.

With high school a distant memory, Jim and Michelle are getting married — and in a hurry, since Jim's grandmother is sick and wants to see him walk down the aisle — prompting Stifler to throw the ultimate bachelor party. And Jim's dad is reliable as ever, doling out advice no one wants to hear.

Everyone has 'moved on', except for Sherman and Jim Levenstein's still understanding father. Little Matt Stiffler wants to join his older brother Steve's business and, after everything Matt has heard from Jim's band-geek wife, he plans to go back to band camp and make a video of his own.

When Erik Stifler realizes that he's the only Stifler family member who might graduate high school a virgin, he decides to live up to his legacy. After some well-meaning advice from Jim's dad, Erik's ready to take his chances at the annual and infamous Naked Mile race, where his devoted friends and some uninhibited sorority girls will create the most outrageous weekend ever.

Erik, Ryan, and Cooze start college and pledge the Beta House fraternity, presided over by none other than legendary Dwight Stifler. But chaos ensues when a fraternity of geeks threatens to stop the debauchery and the Betas have to make a stand for their right to party.

The gang from Dorm Daze is back, but this time they're on a cruise ship on a tropical voyage through the high seas. The cruise makes an educational stop at the island of San Paradiso, where the students are supposed to explore an important archaeological site. Things go from normal to crazy as their visit coincides with every other college's spring break. The moment the boat docks, classes are over! For these Billingsley students, their Semester at Sea will be an adventure no one will ever forget.

In 1954 Florida, a group of high school boys head to a strip club in the Everglades in an attempt to lose their collective virginity. When the club's owner and his sheriff brother swindle them out of their money and embarrass them, the boys plan revenge.

Van Wilder has been attending college for far too many years and is scared to graduate, but Van’s father eventually realizes what is going on. When he stops paying his son's tuition fees, Van must come up with the money if he wants to stay in college, so he and his friends come up with a great fund-raising idea – throwing parties. However, when the college magazine finds out and reporter, Gwen is sent to do a story on Van Wilder, things get a little complicated.

A collection of seven vignettes, which each address a question concerning human sexuality. From aphrodisiacs to sexual perversion to the mystery of the male orgasm, characters like a court jester, a doctor, a queen and a journalist adventure through lab experiments and game shows, all seeking answers to common questions that many would never ask.

Lifelong platonic friends Zack and Miri look to solve their respective cash-flow problems by making an adult film together. As the cameras roll, however, the duo begin to sense that they may have more feelings for each other than they previously thought.