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An enigmatic tale of four people whose lives are intertwined by destiny are subject to the laws of fate. They discover that luck is something they cannot afford to be without as they gamble with the highest stakes possible in a deadly game from which only one of them will emerge intact.

New York gangster Ben 'Bugsy' Siegel takes a brief business trip to Los Angeles. A sharp-dressing womanizer with a foul temper, Siegel doesn't hesitate to kill or maim anyone crossing him. In L.A. the life, the movies, and most of all strong-willed Virginia Hill detain him while his family wait back home. Then a trip to a run-down gambling joint at a spot in the desert known as Las Vegas gives him his big idea.

An old gangster is advised that Freddie Mays would leave jail after thirty years in prison. His mood changes and he recalls when he was a young punk and who joined Freddie's gang—a man he both envied and ultimately betrayed.

Elizabeth has just been through a particularly nasty breakup, and now she's ready to leave her friends and memories behind as she chases her dreams across the country. In order to support herself on her journey, Elizabeth picks up a series of waitress jobs along the way. As Elizabeth crosses paths with a series of lost souls whose yearnings are even greater than her own, their emotional turmoil ultimately helps her gain a greater understanding of her own problems...

Bernie works at a Las Vegas casino, where he uses his innate ability to bring about misfortune in those around him to jinx gamblers into losing. His imposing boss, Shelly Kaplow, is happy with the arrangement. But Bernie finds unexpected happiness when he begins dating attractive waitress Natalie Belisario.

The wife of a international spy arrives in Berlin for a holiday. While her husband is away, she falls in love with a British photographer.

A young reformed gambler must return to playing big stakes poker to help a friend pay off loan sharks.

Jack Manfred is an aspiring writer who to make ends meet, takes a job as a croupier. Jack remains an observer, knowing that everything in life is a gamble and that gamblers are born to lose. Inevitably, he gets sucked into the world of the casino which takes its toll on his relationships and the novel he is writing.

Dan Mahowny was a rising star at the Canadian Imperial Bank of Commerce. At twenty-four he was assistant manager of a major branch in the heart of Toronto's financial district. To his colleagues he was a workaholic. To his customers, he was astute, decisive and helpful. To his friends, he was a quiet, but humorous man who enjoyed watching sports on television. To his girlfriend, he was shy but engaging. None of them knew the other side of Dan Mahowny-the side that executed the largest single-handed bank fraud in Canadian history, grossing over $10 million in eighteen months to feed his gambling obsession.

When fellow operatives and friends disappear during a mission in Hong Kong, Cleopatra Jones comes to help. She discovers the disappearance involves The Dragon Lady, a feared lipstick lesbian who runs a casino and the local drug trade.

A stranger mentors a young Reno gambler who weds a hooker and befriends a vulgar casino regular.