Stage to Mesa City

A man framed for a series of Wells' Fargo stage robberies and a comical sheriff's deputy join forces to uncover the real robbers, unaware that a U.S. Marshal assigned to the case and the Mayor of the town which is at the center of the robberies, are the leaders of the gang.

After Cacopoulos manages to save himself from being hung on a false charge, he robs Cat Stevens and Hutch Bessy of a lot of money and steals their horses. This results in a merry chase and Stevens and Bessy become unwilling allies in Cacopoulus' revenge against the people who deserted him and framed him to get their money back.

Bob Fulton is the superintendent of a mine in the West. He wins the enmity of dancehall owner Jack King when he saves one of the girls, Rose De Braisy, from his unwanted advances. Fulton also wins Rose's love, which he does not return. The mine's owner sends his troublesome son, Roland Holt, out West to work at the mine. Before Holt leaves the East he secretly marries Beth Hoover. Upon Holt's arrival, Fulton tries to befriend him, but Holt prefers the company of bad-guy King.

In order to obtain a stage coach mail contract, a new road must be built. A gang of outlaws try to prevent the building of the road.

An ex-convict (Bob Steele) returns to his ranch; he and his sidekick (Sid Saylor) prove he was framed.

Questions arise when Senator Stoddard attends the funeral of a local man named Tom Doniphon in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance. As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.

The coming of the railroad to Cedar City spells the end of the stagecoach as the government gives the mail contract to the fastest means of delivery. McCord loses the stagecoach line gambling with the new buyer, but has enough hidden money to buy a ranch and some cattle. To make more money, he starts a gang to rob the railroad, express offices and steal cattle. But the railroads send out special agent Cameron to end his reign of violence.

Bandit Cheyenne Harry reforms because of the faith placed in him by Molly Young and her father. Soon, however, Harry is lured from the straight and narrow when he meets his old friend Ben Kent and consents to participate in Kent's plan of robbing a stagecoach.

After her stagecoach is ambushed, a woman is tasked with holding a dangerous outlaw captive and must survive the day when the bandit’s gang tries to free him.

Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.

Double-crossed and left without water in the desert, Cable Hogue is saved when he finds a spring. It is in just the right spot for a much needed rest stop on the local stagecoach line, and Hogue uses this to his advantage. He builds a house and makes money off the stagecoach passengers. Hildy, a prostitute from the nearest town, moves in with him. Hogue has everything going his way until the advent of the automobile ends the era of the stagecoach.