Medicine for Melancholy

Tom and Hannah have been platonic friends for 10 years. He's a serial dater, while she wants marriage but hasn't found Mr. Right. Just as Tom is starting to think that he is relationship material after all, Hannah gets engaged. When she asks Tom to be her 'maid' of honor, he reluctantly agrees just so he can attempt to stop the wedding and woo her.

When actress Sarah Marshall dumps aspiring musician Peter Bretter for rock star Aldous Snow, Peter's world comes crashing down. His best friend Brian suggests that Peter should get away from everything and to fly off to Hawaii to escape all his problems. After arriving in Hawaii and meeting the beautiful receptionist Rachel Jansen, Peter is shocked to see not only Aldous in Hawaii, but also Sarah.

When a young accountant is devastated after discovering his inspiringly beautiful girlfriend is cheating on him, his best friend, who's engaged to a girl he doesn't love, convinces him to go on a "run" and sleep with as many women as he can to get over his heart break.

Rayane, a Lebanese woman, talks with her one-night-stands and lovers about how, strangely, she has great memories of the 2006 Israeli-Lebanese war.

After an extremely regrettable one night stand, two strangers wake up to find themselves snowed in after sleeping through a blizzard that put all of Manhattan on ice. They're now trapped together in a tiny apartment, forced to get to know each other way more than any one night stand should.

Lovestruck Dustin is dating Alexis, his ideal girlfriend, but when she dumps him for coming on too strong, Dustin takes drastic measures to win her back. He asks his best friend Tank to take her on the worst rebound date imaginable - his side job - so that she will come running back to him, and Tank reluctantly agrees. However, Alexis is more than a match for Tank's shock tactics and he begins to really fall for her, leaving him torn between loyalty to Dustin and his growing attraction toward Alexis.

Venereal disease forces a confirmed bachelor to take stock of his history of one night stands.

Tom and Dan's one-night stand turns into an intense power-play between captor and captive.

Adam and Steve are two gay youths who have a one-night stand that ends embarrassingly. Nearly two decades later, Adam, now a Manhattan tour guide, and Steve, a psychiatrist, meet again - but neither remembers the other from years before. The two begin dating, even playing matchmaker for their friends Michael and Rhonda, but their promising relationship hits a major snag when Adam and Steve finally recall their past connection.

At his bachelor party, Jason has a one-night fling with Nikki, a radiant beauty with whom he forms an immediate bond. They agree to keep their secret locked away forever. Two years later, Jason, his wife, Andy and his fiancee plan a reunion weekend. Jason is shocked to discover that Andy's fiancee is Nikki. Now, secret and passionate affairs are played out.

In Los Angeles, Max Carlyle makes a good living directing commercials and has a happy home life with his wife, Mimi, and two children. When Carlyle travels to New York City to visit his friend Charlie, who has been diagnosed with AIDS, he has repeat run-ins with a beautiful woman, Karen, and eventually sleeps with her. Though he goes home the next day and doesn't return until a year later, Carlyle's infidelity still lingers.