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Leonard Shelby is tracking down the man who raped and murdered his wife. The difficulty of locating his wife's killer, however, is compounded by the fact that he suffers from a rare, untreatable form of short-term memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minutes ago, where he's going, or why.

David Aames has it all: wealth, good looks and gorgeous women on his arm. But just as he begins falling for the warmhearted Sofia, his face is horribly disfigured in a car accident. That's just the beginning of his troubles as the lines between illusion and reality, between life and death, are blurred.

After a car crash, criminal psychologist Dr. Miranda Grey regains consciousness only to find that she's a patient in the same mental institution that currently employs her. She's been accused of murdering her husband Dr. Douglas Grey —but she has no memory of committing the crime. As she tries to regain her memory and convince her co-worker, Dr. Pete Graham, of her innocence, a vengeful spirit uses her as an earthly pawn, which further convinces everyone of her guilt.

Minnesota, 1990. Detective Bruce Kenner investigates the case of young Angela, who accuses her father, John Gray, of an unspeakable crime. When John unexpectedly and without recollection admits guilt, renowned psychologist Dr. Raines is brought in to help him relive his memories and what they discover unmasks a horrifying nationwide mystery.

Dan Merrick comes out from a shattering car accident with amnesia. He finds that he is married to Judith who is trying to help him start his life again. He keeps getting flashbacks about events and places that he can't remember. He meets pet shop owner and part time private detective Gus Klein who has supposedly done some work for him prior to the accident. Klein helps Merrick to find out more...

A once-respected surgeon who's lost his family and his memory gets a chance at redemption when he reconnects with someone from his forgotten past.

A famous superstar and paparazzi who followed him happen to fall in love after an accident that causes him to lose his memories.

A husband with a brain disorder that affects his long-term/ short-term memories recounts his marriage & discovers why it’s ending.

A maid at a seaside hotel nurses to health a man she found on the beach who has lost his memory.

A flying saucer lands in the backyard of an elderly suburbanite with memory problems, who forms a bond with the scared alien inside.