The Disappearance of Lady Frances Carfax

Having once again avoided criminal conviction, Professor Moriarity develops a murderous plan to “finish off” his last major nemesis, Sherlock Holmes, by making him fail to prevent the perfect crime. Does it involve a family curse, the crown jewels of England, or something else…

Eccentric consulting detective Sherlock Holmes and Doctor John Watson battle to bring down a new nemesis and unravel a deadly plot that could destroy England.

Sherlock Holmes and Dr. Watson meet as boys in an English Boarding school. Holmes is known for his deductive ability even as a youth, amazing his classmates with his abilities. When they discover a plot to murder a series of British business men by an Egyptian cult, they move to stop it.

When a nobleman is threatened by a family curse on his newly inherited estate, detective Sherlock Holmes is hired to investigate.

Sherlock Holmes and Dr. Watson look into reports that a huge, vicious hound has killed Lord Charles Baskerville and that Lord Henry Baskerville is the next to be killed.

Holmes receives a mysterious telegram from Cyril Overton, the captain of the Cambridge University rugby team. Overton later explains that one of the best players on his team, a young man named Godfrey Staunton, went missing while in London for an important game. Holmes follows a trail of clues back to Cambridge.

A governess is arrested for the murder of her employer's wife.

A gentleman is baffled when the childish drawings of little dancing men terrify his American wife. Sherlock Holmes soon discovers why.

Susan Cushing asks Holmes' help in solving the disappearance of her sister Mary Browner, but it doesn't seem Holmes' type of case until he is told of a Christmas present's grisly contents.

Hilton Soames, a lecturer in Greek at a university, notices that someone has gone into his study and looked at the text for an unseen translation exam that is due to take place the next day. Suspicion falls on the three students who live in the same building in which Soames lives and works, all of whom are entered for the exam.

Dr. John Watson treats a patient who has lost a thumb. The patient says that the loss of his thumb was not an accident but the result of an attack. However, he fears that the story behind the loss of his digit is so strange that the police will not believe it.